Violent-Agitated Date Last Search Run: Sep 12, 2023 Data last added: Jul 18, 2023

Recommendation		RECOMMENDATION FOR INTERVENTION
STRENGTH OF EVIDENCE FOR INTERVENTION		SUPPORTIVE (Green)	NEUTRAL (Yellow)	AGAINST (Red)	NOT YET GRADED (White)
	1 (strong evidence exists)
	2 (fair evidence exists)	Benzodiazepines Ketamine
	3 (weak evidence exists)	Antipsychotics

Interventions

Antipsychotics

Level	Direction	Primary Outcome	Patient/Process	Setting	Reference
III	Supportive (Green)	Efficacy and Safety	Patient	ED-MD	Ramsden SC, Pergjika A, Janssen AC, Mudahar S, Fawcett A, Walkup JT, Hoffmann JA. A systematic review of the effectiveness and safety of droperidol for pediatric agitation in acute care settings. Acad Emerg Med 2022. Medline

Benzodiazepines

Level	Direction	Primary Outcome	Patient/Process	Setting	Reference
II	Supportive (Green)	Improvement	Patient	PH-Paramedic	Sandoval S, Goyal A, Frawley J, et al. Prehospital Use of Ketamine versus Benzodiazepines for Sedation among Pediatric Patients with Behavioral Emergencies. Prehosp Emerg Care 2023;1-7. Medline

Ketamine

Level	Direction	Primary Outcome	Patient/Process	Setting	Reference
II	Supportive (Green)	Safety	Patient	PH-Paramedic	Goyal A, Frawley J, Gappy R, Sandoval S, Chen NW, Crowe R, Swor R. Prehospital Ketamine Use in Pediatrics. Prehosp Emerg Care 2022; 1–11 Medline
II	Supportive (Green)	Improvement	Patient	PH-Paramedic	Sandoval S, Goyal A, Frawley J, et al. Prehospital Use of Ketamine versus Benzodiazepines for Sedation among Pediatric Patients with Behavioral Emergencies. Prehosp Emerg Care 2023;1-7. Medline