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Pediatric Anaphylaxis

Date Last Search Run: May 17, 2023
Table last updated: Aug 21, 2022
Data last added: Aug 19, 2022

Recommendation RECOMMENDATION FOR INTERVENTION
STRENGTH OF EVIDENCE FOR INTERVENTION   SUPPORTIVE (Green) NEUTRAL (Yellow) AGAINST (Red) NOT YET GRADED (White)
1 (strong evidence exists)      
2 (fair evidence exists)    
3 (weak evidence exists)      


Interventions

Beta Agonist-Nebulized
Level Direction Primary Outcome Patient/Process Setting Reference

Crystalloid Infusion
Level Direction Primary Outcome Patient/Process Setting Reference

Diphenhydramine
Level Direction Primary Outcome Patient/Process Setting Reference

Epinephrine
Level Direction Primary Outcome Patient/Process Setting Reference
II Supportive (Green) Disposition (home, observation, in-patient unit, intensive care unit). Patient PH-Paramedic Trainor JL, Pittsenbarger ZE, Joshi D, Adler MD, Smith B, Gupta RS. Outcomes and Factors Associated With Prehospital Treatment of Pediatric Anaphylaxis. Pediatr Emerg Care 2022; 38(1):e69–74. Medline
III Supportive (Green) Survival Patient PH-Paramedic Chipps BE. Update in pediatric anaphylaxis: a systematic review. Clin Pediatr (Phila) 2013; 52(5):451-61. Medline
III Supportive (Green) Clinical benefit Patient PH-Paramedic Fortenberry JE., Laine J., Shalit M. Use of epinephrine for anaphylaxis by emergency medical technicians in a wilderness setting. Ann Emerg Med 1995; 25(6):785-7. Medline
III Supportive (Green) Recognition and management Process PH-Paramedic Lindbeck GH., Burns DM., Rockwell DD. Out-of-hospital provider use of epinephrine for allergic reactions: Pilot program. Acad Emerg Med 1995; 2(7):592-6. Medline
III Neutral (Yellow) Adverse Events Patient PH-Paramedic Safdar B., Cone DC., Pham KT. Subcutaneous epinephrine in the prehospital setting. Prehosp Emerg Care 2001; 5(2):200-7. Medline

Glucagon
Level Direction Primary Outcome Patient/Process Setting Reference

Inotrope
Level Direction Primary Outcome Patient/Process Setting Reference

Steroid
Level Direction Primary Outcome Patient/Process Setting Reference


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