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Opioid withdrawal

Date Last Search Run: Feb 01, 2022
Table last updated: Aug 01, 2022
Data last added: Jun 24, 2022

Recommendation RECOMMENDATION FOR INTERVENTION
STRENGTH OF EVIDENCE FOR INTERVENTION   SUPPORTIVE (Green) NEUTRAL (Yellow) AGAINST (Red) NOT YET GRADED (White)
1 (strong evidence exists)        
2 (fair evidence exists)      
3 (weak evidence exists)    


Interventions

Buprenorphine
Level Direction Primary Outcome Patient/Process Setting Reference
III Supportive (Green) Prevention of withdrawal symptoms Patient ED-MD Carroll GG, Wasserman DD, Shah AA, Salzman MS, Baston KE, Rohrbach RA, Jones IL, Haroz R. Buprenorphine Field Initiation of ReScue Treatment by Emergency Medical Services (Bupe FIRST EMS): A Case Series. Prehosp Emerg Care. 2021 Mar-Apr;25(2):289-293. doi: 10.1080/10903127.2020.1747579. Epub 2020 May 4. PMID: 32208945. Medline
III Supportive (Green) demographic description and patient experience with buprenorphine Patient Other Robbins M, Haroz R, Mazzarelli A, 4th Clements D, Jones CW, Salzman M. Buprenorphine use and disparities in access among emergency department patients with opioid use disorder: A cross-sectional study. J Subst Abus Treat 2021; 130:108405. Medline
X Not Yet Graded (White) - Hern HG, Goldstein D, Kalmin M, Kidane S, Shoptaw S, Tzvieli O, Herring AA. Prehospital Initiation of Buprenorphine Treatment for Opioid Use Disorder by Paramedics. Prehosp Emerg Care. 2021 Nov 22:1-7. doi: 10.1080/10903127.2021.1977440. Epub ahead of print. PMID: 34505820. Medline
X Not Yet Graded (White) - Krenz JR, Hayes BD, Wakeman SE, Martin A, Raja AS, White BA, Koehl JL. Continuation of outpatient buprenorphine therapy after dispensing Buprenorphine-Naloxone from the emergency department. Clin Toxicol 2022; 60(4):429–32. Medline
X Not Yet Graded (White) - Regan S, Howard S, Powell E, Martin A, Dutta S, Hayes BD, et al. Emergency Department-initiated Buprenorphine and Referral to Follow-up Addiction Care: A Program Description. J Addict Med 2022; 16(2):216–22. Medline


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