Antidopaminergic
Level |
Direction |
Primary Outcome |
Patient/Process |
Setting |
Reference |
I
|
Neutral (Yellow)
|
Nausea score
|
Patient
|
In-Patient
|
Fletcher D., Coyne P., Dodson P., Parker G., Wan W., Smith T. A Randomized Trial of the Effectiveness of Topical “ABH Gel” (Ativan®, Benadryl®, Haldol®) vs. Placebo in Cancer Patients With Nausea. J Pain Symp Mngmnt 2014; 48(5):797-803. Medline
|
I
|
Neutral (Yellow)
|
Reduction nausea
|
Patient
|
In-Patient
|
Murray-Brown F., Dorman S. Haloperidol for the treatment of nausea and vomiting in palliative care patients. Cochrane Database Syst Rev 2015; 11:CD006271. Medline
|
II
|
Neutral (Yellow)
|
Nausea and Vomiting relief
|
Patient
|
In-Patient
|
Hardy J., O’Shea A., White C. The Efficacy of Haloperidol in the Management of Nausea and Vomiting in Patients with Cancer. J of Pain and Symp Mngmnt 2010; 40(1):111-6. Medline
|
III
|
Supportive (Green)
|
Nausea control
|
Patient
|
In-Patient
|
Cole R., Robinson F., Harvey L., et al. Successful control of intractable nausea and vomiting requiring combined ondansetron and haloperidol on a patient with advanced cancer. J of Pain and sym mngmnt 1994; 9(1):48-50. Medline
|
III
|
Neutral (Yellow)
|
Nausea and vomiting
|
Patient
|
In-Patient
|
Davis M., Hallerberg G. A Systematic Review of the Treatment of Nausea and/or Vomiting in Cancer Unrelated to Chemotherapy or Radiation. J of Pain and Sym mngmnt 2010; 39(4):756-67. Medline
|
Levomepromazine
Level |
Direction |
Primary Outcome |
Patient/Process |
Setting |
Reference |
III
|
Supportive (Green)
|
Reduction of Nausea
|
Patient
|
In-Patient
|
Eisenchlas J., Garrigue N., Junin M., De Simone G. Lowdose levomepromazine in refractory emesis in advanced cancer patients: an open-label study. Palliative Medicine 2005; 19:71–5. Medline
|
III
|
Supportive (Green)
|
Patient rating of nausea and/or vomiting
|
Patient
|
In-Patient
|
Kennet A., Hardy J., Shah S., A’Hern R. An open study of methotrimeprazine in the management of nausea and vomiting in patients with advanced cancer. Support Cancer Care 2004; 13:715–21. Medline
|
III
|
Neutral (Yellow)
|
Reduction in nausea or vomiting
|
Patient
|
In-Patient
|
Glare P., Pereira G., Kristjanson L., et al. Systematic review of the efficacy of antiemetics in the treatment of nausea in patients with far-advanced cancer. Support Care Cancer 2004; 12:432–40. Medline
|