Mild Allergic Reaction Date Last Search Run: Aug 01, 2024 Table last updated: Dec 09, 2019 Data last added: Sep 14, 2009

Recommendation		RECOMMENDATION FOR INTERVENTION
STRENGTH OF EVIDENCE FOR INTERVENTION		SUPPORTIVE (Green)	NEUTRAL (Yellow)	AGAINST (Red)	NOT YET GRADED (White)
	1 (strong evidence exists)	Diphenhydramine
	2 (fair evidence exists)
	3 (weak evidence exists)

Interventions

Diphenhydramine

Level	Direction	Primary Outcome	Patient/Process	Setting	Reference
I	Supportive (Green)	Resolution of symptoms	Patient	ED-MD	Lin Y., et al. Improved outcomes in patients with acute allergic syndromes who are treated with combined H1 and H2 antagonists. Ann Emerg Med 2000; 36:462 Medline
I	Supportive (Green)	Clinically significant relief	Patient	ED-MD	Runge WJ., Martinez JC., Caravati EM., et al. Histamine antagonists in the treatment of acute allergic reactions. Ann Emerg Med 1992; 21(3):237-42. Medline