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Hyperthermia

Date Last Search Run: Jan 14, 2025
Table last updated: Jan 28, 2025
Data last added: Dec 19, 2024

Recommendation RECOMMENDATION FOR INTERVENTION
STRENGTH OF EVIDENCE FOR INTERVENTION   SUPPORTIVE (Green) NEUTRAL (Yellow) AGAINST (Red) NOT YET GRADED (White)
1 (strong evidence exists)      
2 (fair evidence exists)    
3 (weak evidence exists)  


Interventions

External Cooling
Level Direction Primary Outcome Patient/Process Setting Reference
III Supportive (Green) Cooling rate Patient PH-Paramedic DeGroot DW, Henderson KN, O'Connor FG. Cooling Modality Effectiveness and Mortality Associate With Prehospital Care of Exertional Heat Stroke Casualities. J Emerg Med 2023. Medline
III Supportive (Green) Core temperature Process SIM Flouris AD., Friesen BJ., Carlson MJ., Casa DJ., Kenny GP. Effectiveness of cold water immersion for treating exertional heat stress when immediate response is not possible. Scand J Med Sci Sports 2015; 25(S1):229-39. Medline
III Supportive (Green) Ability of on scene cooling to achieve a core temp <102.2 F Patient PH-Paramedic Jacobsen RC, Beaver B, Abo B. Out-of-Hospital Cold Water Immersion for Classic (Non-Exertional) Heat Stroke Guided by Real-Time Core Temperature Monitoring: A Case Series. Prehosp Emerg Care Nov 2022; 1–6. Medline
III Supportive (Green) Reduction in body temperature Patient PH-Paramedic & MD Kido N, Tagami T, Otake K, et al. Exploring the Potential of CarbonCool® in Rapid Prehospital Cooling for Severe Heat Stroke. Prehosp Emerg Care February 2024; 1-17. Medline
III Supportive (Green) Rate of cooling Process Luhring KE., Butts CL., Smith CR., et al. Cooling effectiveness of a modified cold-water immersion method after exercise-induced hyperthermia. Journal of athletic training. 2016;51(11):946-951. Medline
III Supportive (Green) Successful discharge at 6 hours with no long-term adverse effects Process PH-Bystander Rogerson S, Brearley M. Suspected exertional heat stroke; A case study of worker cooling in a hot and humid field environment. Work. July 2024. Medline
III Supportive (Green) Efficacy Patient PH-Paramedic Young D, Everitt B, Fine B, Miramontes D. Immersive Cooling in the Prehospital Setting for Heat Stroke: A Case Report. Prehosp Emerg Care April 2023:1-3. Medline
X Not Yet Graded (White) Detection cold hyperthermia Process Lissoway JB., Lipman GS., Grahn DA., et al. Novel application of chemical cold packs for treatment of exercise-induced hyperthermia: A randomized controlled trial. Wilderness Environ Med 2015; 26(2):173-9. Medline

IV Fluid as a cooling agent
Level Direction Primary Outcome Patient/Process Setting Reference
III Supportive (Green) Decrease in core body temperature Process ED-MD Bursey MM, Galer M, Oh RC, Weathers BK. Successful Management of Severe Exertional Heat Stroke with Endovascular Cooling After Failure of Standard Cooling Measures. J Emerg Med 2019; 57(2):e53-6. Medline
III Neutral (Yellow) Mental status Patient Horseman MA., Rather-Conally J., Saavedra C., Surani S. A case of severe heatstroke and review of pathophysiology, clinical presentation, and treatment. J Intensive Care Med 2013; 28(6):334-40. Medline
X Not Yet Graded (White) - Patient Mallick A., Bodenham AR. MDMA induced hyperthermia: A survivor with an initial body temperature of 42.9 degrees C. J Accid Emerg Med 1997; 14(5):336-8. Medline

Oral rehydration
Level Direction Primary Outcome Patient/Process Setting Reference

Temperature Monitoring
Level Direction Primary Outcome Patient/Process Setting Reference
II Neutral (Yellow) Sensitivity and Specificity Process Niven DJ., Gaudet JE., Laupland KB., Mrklas KJ., Roberts DJ., Stelfox HT. Accuracy of Peripheral Thermometers for Estimating Temperature: A Systematic Review and Meta-analysis. Ann Intern Med 2015; 163:768-77. Medline


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