ETOH Withdrawal Date Last Search Run: May 17, 2023 Table last updated: Mar 31, 2023 Data last added: Feb 27, 2023

Recommendation		RECOMMENDATION FOR INTERVENTION
STRENGTH OF EVIDENCE FOR INTERVENTION		SUPPORTIVE (Green)	NEUTRAL (Yellow)	AGAINST (Red)	NOT YET GRADED (White)
	1 (strong evidence exists)
	2 (fair evidence exists)	Benzodiazepines
	3 (weak evidence exists)

Interventions

Benzodiazepines

Level	Direction	Primary Outcome	Patient/Process	Setting	Reference
II	Supportive (Green)	Medicating acute alcohol withdrawal.	Patient	In-Patient	Lebin JA, Mudan A, Murphy CE 4th, Wang RC, Smollin CG. Return Encounters in Emergency Department Patients Treated with Phenobarbital Versus Benzodiazepines for Alcohol Withdrawal. J Med Toxicol 2022; 18(1):4–10. Medline
II	Supportive (Green)	Control of agitation from Impact on 1) ED LOS 2) hospital admission alcohol withdrawal.	Process	ED-MD	Levine AR, Thanikonda V, Mueller J, Naut ER. Front-loaded diazepam versus lorazepam for treatment of alcohol withdrawal agitated delirium. Am J Emerg 2021; 44:415–8. Medline
II	Neutral (Yellow)	-	Patient	ED-MD	Pistore A, Penney S, Bryce R, Meyer C, Bouchard B. A retrospective evaluation of phenobarbital versus benzodiazepines for treatment of alcohol withdrawal in a regional Canadian emergency department. Alcohol 2022;102:59–65. Medline