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Cannabinoid hyperemesis

Date Last Search Run: Jan 14, 2025
Table last updated: Jan 29, 2025
Data last added: Jan 28, 2025

Recommendation RECOMMENDATION FOR INTERVENTION
STRENGTH OF EVIDENCE FOR INTERVENTION   SUPPORTIVE (Green) NEUTRAL (Yellow) AGAINST (Red) NOT YET GRADED (White)
1 (strong evidence exists)        
2 (fair evidence exists)    
3 (weak evidence exists)      


Interventions

Capsaicin
Level Direction Primary Outcome Patient/Process Setting Reference
II Supportive (Green) Admission prevalence; symptom resolution Patient In-Patient Pourmand A, Esmailian G, Mazer-Amirshahi M, Lee-Park O, Tran QK. Topical capsaicin for the treatment of cannabinoid hyperemesis syndrome, a systematic review and meta-analysis. Am J Emerg Med 2021; 43:35–40. Medline
II Neutral (Yellow) Reduction in nausea and emesis Patient ED-MD Sabbineni M, Scott W, Punia K, et al. SAEM GRACE: Dopamine antagonists and topical capsaicin for cannabis hyperemesis syndrome in the emergency department: A systematic review of direct evidence. Acad Emerg Med May 2024; 31(5):493-503. Medline


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