Altered Mental Status (NYD)
Date Last Search Run: Jan 14, 2025
Table last updated: Dec 12, 2017
Recommendation
RECOMMENDATION FOR INTERVENTION
STRENGTH OF EVIDENCE FOR INTERVENTION
 
SUPPORTIVE (Green)
NEUTRAL (Yellow)
AGAINST (Red)
NOT YET GRADED (White)
1 (strong evidence exists)
 
 
 
D50W
Ketamine
2 (fair evidence exists)
 
 
 
3 (weak evidence exists)
Naloxone
 
 
Interventions
D50W
Level
Direction
Primary Outcome
Patient/Process
Setting
Reference
Ketamine
Level
Direction
Primary Outcome
Patient/Process
Setting
Reference
Naloxone
Level
Direction
Primary Outcome
Patient/Process
Setting
Reference
III
Supportive (Green)
Adverse events following naloxone
Patient
PH-Paramedic
Yealy DM., Paris PM., Kaplan RM., et al. The safety of prehospital naloxone administration by paramedics. Ann Emerg Med 1990; 19(8):95-98.
Medline
III
Neutral (Yellow)
Response to naloxone
Process
SIM
Hoffman JR., Schriger DL., Votey DL., et al. The empiric use of hypertonic narcan in patients with altered mental status: A reappraisal. Ann Emerg Med 1992; 21(1):20-4.
Medline
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