Sedation


COCHRANE SYSTEMATIC REVIEW: The use of propofol for procedural sedation in emergency departments Implication for practice: Little evidence in this area
Implications for practice: Little evidence in this area
Review Overview: We reviewed the evidence regarding the use of propofol to sedate people in the ED undergoing painful medical procedures. We wanted to discover the effectiveness and safety of propofol compared with other drugs used to sedate people in the ED. Study characteristics The evidence obtained is current to September 2013. We re-ran the search in February 2015 and we will deal with the study awaiting classification when we update the review. We included 10 studies involving 813 participants. The included studies compared propofol with five other alternative drugs used to sedate people in the ED. We could not pool the results of the 10 studies because no two studies compared the same drug options. No firm conclusions can be drawn concerning the comparative effects of administering intravenous propofol, with or without an adjunctive analgesic agent, with alternative interventions in participants undergoing PS in the ED setting on adverse effects (including pain at the injection site) and participant satisfaction. The review was limited because no two included studies employed the same comparator interventions, and because the number of participants in eight of the included studies were small (fewer than 100 participants).
LINK to Cochrane Library: Issue 10, 2015 http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD007399.pub2/abstract